| 1 | Pirates of the Caribbean: At World's End (Disney) | May 25 - May 27, 2007 | $139,803,335 | 4,362 | $32,050 | 1 |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull (Paramount) | May 23 - May 25, 2008 | $126,917,504 | 4,260 | $29,793 | 1 |
| 3 | X-Men: The Last Stand (Fox) | May 26 - May 28, 2006 | $122,860,968 | 3,690 | $33,296 | 1 |
| 4 | The Hangover Part II (Warner Bros.) | May 27 - May 29, 2011 | $103,426,875 | 3,615 | $28,610 | 1 |
| 5 | Shrek 2 (DreamWorks) | May 28 - May 30, 2004 | $95,581,379 | 4,223 | $22,634 | 2 |
| 6 | The Lost World: Jurassic Park (Universal) | May 23 - May 25, 1997 | $90,161,484 | 3,281 | $27,480 | 1 |
| 7 | The Day After Tomorrow (Fox) | May 28 - May 30, 2004 | $85,807,484 | 3,425 | $25,053 | 1 |
| 8 | Bruce Almighty (Universal) | May 23 - May 25, 2003 | $85,734,067 | 3,483 | $24,615 | 1 |
| 9 | Pearl Harbor (Disney) | May 25 - May 27, 2001 | $75,176,802 | 3,214 | $23,390 | 1 |
| 10 | Mission: Impossible II (Paramount) | May 26 - May 28, 2000 | $70,816,603 | 3,653 | $19,386 | 1 |
| 11 | Night at the Museum: Battle of the Smithsonian (Fox) | May 22 - May 24, 2009 | $70,051,276 | 4,096 | $17,102 | 1 |
| 12 | Star Wars: Episode III - Revenge of the Sith (Fox) | May 27 - May 29, 2005 | $70,046,753 | 3,663 | $19,123 | 2 |
| 13 | Shrek the Third (Paramount / DreamWorks) | May 25 - May 27, 2007 | $67,011,704 | 4,172 | $16,062 | 2 |
| 14 | Star Wars: Episode I - The Phantom Menace (Fox) | May 28 - May 30, 1999 | $66,904,392 | 3,023 | $22,132 | 2 |
| 15 | Madagascar (DreamWorks) | May 27 - May 29, 2005 | $61,011,185 | 4,131 | $14,769 | 1 |
| 16 | Kung Fu Panda 2 (Paramount / DreamWorks) | May 27 - May 29, 2011 | $60,871,175 | 3,925 | $15,509 | 1 |
| 17 | Star Wars: Episode II - Attack of the Clones (Fox) | May 24 - May 26, 2002 | $60,003,481 | 3,161 | $18,982 | 2 |
| 18 | The Longest Yard (2005) (Paramount) | May 27 - May 29, 2005 | $58,614,416 | 3,634 | $16,129 | 1 |
| 19 | Shrek Forever After (Paramount / DreamWorks) | May 28 - May 30, 2010 | $57,060,434 | 4,367 | $13,066 | 2 |
| 20 | Mission: Impossible (Paramount) | May 24 - May 26, 1996 | $56,810,803 | 3,012 | $18,861 | 1 |
| 21 | Godzilla (1998) (Sony / TriStar) | May 22 - May 24, 1998 | $55,727,509 | 3,310 | $16,836 | 1 |
| 22 | Shrek (DreamWorks) | May 25 - May 27, 2001 | $55,215,689 | 3,623 | $15,240 | 2 |
| 23 | Terminator Salvation (Warner Bros.) | May 22 - May 24, 2009 | $51,943,275 | 3,530 | $14,715 | 1 |
| 24 | Pirates of the Caribbean: On Stranger Tides (Disney) | May 27 - May 29, 2011 | $50,012,338 | 4,164 | $12,011 | 2 |
| 25 | The Matrix Reloaded (Warner Bros.) | May 23 - May 25, 2003 | $45,613,030 | 3,603 | $12,660 | 2 |
| 26 | The Da Vinci Code (Sony / Columbia) | May 26 - May 28, 2006 | $42,437,547 | 3,754 | $11,305 | 2 |
| 27 | Twister (1996) (Warner Bros.) | May 24 - May 26, 1996 | $37,967,242 | 2,808 | $13,521 | 3 |
| 28 | Prince of Persia: The Sands of Time (Disney) | May 28 - May 30, 2010 | $37,813,075 | 3,646 | $10,371 | 1 |
| 29 | The Flintstones (Universal) | May 27 - May 29, 1994 | $37,182,946 | 2,498 | $14,885 | 1 |
| 30 | Indiana Jones and the Last Crusade (Paramount) | May 26 - May 28, 1989 | $37,032,418 | 2,327 | $15,914 | 1 |
| 31 | Sex and the City 2 (Warner Bros. / New Line) | May 28 - May 30, 2010 | $36,835,000 | 3,445 | $10,692 | 1 |
| 32 | Spider-Man (Sony / Columbia) | May 24 - May 26, 2002 | $35,815,910 | 3,876 | $9,240 | 4 |
| 33 | Over the Hedge (Paramount / DreamWorks) | May 26 - May 28, 2006 | $35,322,226 | 4,093 | $8,630 | 2 |
| 34 | Indiana Jones and the Temple of Doom (Paramount) | May 25 - May 27, 1984 | $33,936,301 | 1,687 | $20,116 | 1 |
| 35 | Beverly Hills Cop II (Paramount) | May 22 - May 24, 1987 | $33,013,933 | 2,326 | $14,193 | 1 |
| 36 | Dinosaur (Disney) | May 26 - May 28, 2000 | $32,038,631 | 3,302 | $9,703 | 2 |
| 37 | Return of the Jedi (Fox) | May 27 - May 29, 1983 | $30,492,610 | 1,002 | $30,432 | 1 |
| 38 | The Chronicles of Narnia: Prince Caspian (Disney) | May 23 - May 25, 2008 | $29,809,281 | 3,929 | $7,587 | 2 |
| 39 | Star Trek (Paramount) | May 22 - May 24, 2009 | $29,380,943 | 4,053 | $7,249 | 3 |
| 40 | Notting Hill (Universal) | May 28 - May 30, 1999 | $27,690,004 | 2,747 | $10,080 | 1 |
| 41 | Lethal Weapon 3 (Warner Bros.) | May 22 - May 24, 1992 | $27,567,462 | 2,510 | $10,983 | 2 |
| 42 | Angels & Demons (Sony / Columbia) | May 22 - May 24, 2009 | $27,414,795 | 3,527 | $7,773 | 2 |
| 43 | Iron Man (Paramount) | May 23 - May 25, 2008 | $26,110,837 | 3,915 | $6,669 | 4 |
| 44 | Insomnia (2002) (Warner Bros.) | May 24 - May 26, 2002 | $26,068,608 | 2,610 | $9,988 | 1 |
| 45 | Rambo: First Blood Part II (TriStar) | May 24 - May 26, 1985 | $25,170,778 | 2,074 | $12,136 | 1 |
| 46 | Crocodile Dundee II (Paramount) | May 27 - May 29, 1988 | $24,462,976 | 2,837 | $8,623 | 1 |
| 47 | Back to the Future Part III (Universal) | May 25 - May 27, 1990 | $23,701,502 | 2,019 | $11,739 | 1 |
| 48 | Spirit: Stallion of the Cimarron (DreamWorks) | May 24 - May 26, 2002 | $23,214,225 | 3,317 | $6,999 | 1 |
| 49 | Alien³ (Fox) | May 22 - May 24, 1992 | $23,140,467 | 2,227 | $10,391 | 1 |
| 50 | Casper (Universal) | May 26 - May 28, 1995 | $22,093,196 | 2,714 | $8,140 | 1 |
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